New county- and state-level data help show where PrEP use is growing, where unmet need remains, and that access to HIV prevention services continues to vary across the U.S.
Atlanta, GA, June 25, 2026— Today, AIDSVu released 2025 data on PrEP use across the United States, showing that PrEP use continued to increase nationally in 2025 to over 644K people using PrEP for HIV prevention – a record high. However, the 10% increase from 2024 to 2025 was the smallest annual increase observed in the past five years, signaling a potential slowdown in the nation’s progress toward expanding access to one of the most effective HIV prevention tools available.
The new data, available only on AIDSVu’s interactive maps, state and county profiles, and PrEPVu.org, provide a clearer picture of where PrEP use is increasing, where unmet need remains, and where funding and resources should be focused to expand PrEP access and end the HIV epidemic.
PrEP, or pre-exposure prophylaxis, significantly reduces an individual’s chances of getting HIV. When taken as prescribed, PrEP is highly effective for preventing HIV and can reduce the risk of getting HIV by as much as 99%. Yet many people who could benefit from PrEP continue to face barriers to accessing it, including limited awareness of HIV and PrEP, stigma, provider availability, insurance coverage challenges, affordability, transportation barriers, and broader social determinants of health such as poverty and housing instability.
The 2025 PrEP use data show that progress in PrEP uptake continues to vary widely across regions and communities. The South accounted for 39% of PrEP users in 2025, while representing 52% of new HIV diagnoses in 2024. The region also had the lowest PrEP-to-Need Ratio*, indicating the greatest unmet need for PrEP.
The data also highlight persistent racial and ethnic gaps in PrEP use. In the South, Black people represented 48% of new HIV diagnoses in 2024 but only 23% of PrEP users in 2025. In the West, Hispanic people represented 51% of new HIV diagnoses in 2024 but only 25% of PrEP users in 2025. These disparities underscore the need for increased investment in accessible, culturally relevant HIV prevention education and services that are tailored to the needs of Black and Hispanic communities, as well as policies that address the structural barriers affecting access to HIV prevention.
“Local data are essential because HIV prevention is local. A national increase in PrEP use does not mean every community has the access it needs. County-level data can help identify where prevention infrastructure is working, where gaps remain, and where additional resources may be needed,” said Dr. Patrick Sullivan, Professor of Epidemiology at Emory University and Principal Scientist for AIDSVu.
The 2025 data arrive at a critical moment for HIV prevention. Federal HIV prevention funding and programs – which support testing, education, outreach, provider training, and PrEP services – continue to be under threat, and uncertainty exists around the future of the U.S. Preventive Services Task Force (USPSTF) and the Grade A PrEP recommendation, which could jeopardize federal protections that eliminate cost-sharing barriers to PrEP for most insured individuals. AIDSVu’s data illustrate the progress we have made as a nation in expanding PrEP use and where we need to continue to focus to ensure that PrEP is available and accessible to everyone who can benefit from it.
“PrEP remains one of the most powerful tools we have to prevent HIV, but access and uptake is still far too uneven,” said Dr. Sullivan, “The data on AIDSVu make clear that progress is possible when prevention is prioritized, while also showing where unmet need remains. Awareness, stigma, insurance coverage, and provider access can all determine whether people are able to start PrEP and remain on it over time. Federal and state governments must continue investing in HIV prevention, expanding access to PrEP, and directing resources to the communities most impacted by HIV. Policymakers, public health leaders, and community organizations all have a role to play in ensuring that PrEP reaches the people who need it most.”
Key Findings from the 2025 PrEP Data
- PrEP use continues to grow, but progress is slowing.
In 2025, 644,170 people were on PrEP in the United States – the highest number of annual PrEP users to date. PrEP use increased 10% from 2024 to 2025, marking the smallest annual increase observed in the past five years. - Young people and women continue to have a high unmet need for PrEP.
People ages 13 to 24 made up only 10% of all PrEP users in 2025, despite accounting for 18% of new HIV diagnoses in 2024.
Women accounted for 10% of PrEP users in 2025 but represented 20% of new HIV diagnoses in 2024, underscoring the need to expand PrEP awareness and access among women.
- The South continues to face the greatest unmet need for PrEP across regions.
The South accounted for 53% of new HIV diagnoses in 2024 but only 39% of PrEP users in 2025 and had the lowest regional PnR at 12 (12 PrEP users for every new HIV diagnosis in the region). In comparison, the Northeast had a PnR of 26, the Midwest had a PnR of 18, and the West had a PnR of 20. - Disparities in PrEP use across racial and ethnic groups persist.
In 2025, the PrEP-to-Need Ratio for Black and Hispanic people continued to be much lower than the PnR for white people across all regions of the U.S., indicating a greater unmet need for PrEP among Black and Hispanic people and ongoing gaps in access to HIV prevention services.- Black people represented 39% of all new HIV diagnoses in 2024, the highest among all racial/ethnic groups, but accounted for only 15% of PrEP users in 2025.
- Hispanic people represented 34% of new HIV diagnoses in 2024 but accounted for only 18% of PrEP users in 2025.
- White people represented 21% of new HIV diagnoses in 2024 but accounted for 63% of all PrEP users in 2025.
- Almost half of all PrEP users in the U.S. in 2025 lived in the 48 counties prioritized by the federal Ending the HIV Epidemic (EHE) initiative.
One of the four key strategies of the EHE initiative is to prevent new HIV transmissions by using proven interventions, including PrEP. Almost half (49%) of all PrEP users in the U.S. in 2025 lived in the 48 counties prioritized by the federal Ending the HIV Epidemic (EHE) initiative and almost half (47%) of all new HIV diagnoses were in an EHE county in 2024, underscoring the importance of the federal EHE initiative in increasing PrEP use in geographies with the highest burden of HIV.
- Between 2019 and 2025, the number of PrEP users in EHE counties increased from 139,138 to 314,376. In that same period, the PrEP-to-Need Ratio in the 48 EHE counties increased by an average of 160%, meaning more individuals with a need for PrEP were on PrEP.
About AIDSVu
AIDSVu is a project of Emory University’s Rollins School of Public Health in partnership with Gilead Sciences, Inc. and the Center for AIDS Research at Emory University. AIDSVu makes HIV data widely available, easily accessible, and locally relevant to inform public health decision-making and action.
AIDSVu provides interactive maps, data visualizations, profiles, infographics, downloadable datasets, and public health resources to help users understand HIV and HIV prevention across the United States.
About PrEPVu
PrEPVu is a resource from AIDSVu that visualizes PrEP use and unmet need for PrEP across the United States. Through interactive maps, downloadable datasets, profiles, service locators, and data-driven analyses, PrEPVu helps public health officials, policymakers, researchers, advocates, and community members better understand PrEP access and HIV prevention needs at the national, regional, state, and county levels.
PrEPVu includes updated maps of PrEP use and PrEP-to-Need Ratios by geography and demographic characteristics, as well as tools to help users identify local PrEP providers and better understand barriers to prevention access.
About the Data
The PrEP use data on AIDSVu are made possible through a data-sharing agreement in which data were obtained from IQVIA with the support of Gilead Sciences, Inc., and compiled by researchers at the Rollins School of Public Health at Emory University.
*The PrEP-to-Need Ratio, or PnR, is the ratio of the number of PrEP users to the number of people newly diagnosed with HIV. A lower PnR indicates more unmet need for PrEP. 2025 and 2024 PnR were calculated using 2023 new diagnoses as the denominator.
